I like this name for a girl because: A) it's the name of my favorite all-time album and song (by Uncle Tupelo); B) it means something that soothes. For short, we would call her Ana, Ann or perhaps Annie.

Here's what Merriam-Webster has to say about Anodyne:

  1. : something that soothes, calms, or comforts "the anodyne of bridge, a comfortable book, or sport" -- Harrison Smith
  2. : a drug that allays pain

Latin anodynos, from Greek andynos, from a- "not" + odyne "pain"; probably akin to Old English etan "to eat"
  1. : serving to assuage pain
  2. : not likely to offend or arouse tensions: INNOCUOUS

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